
T (+98) 23 352 20220
Email: international@du.ac.ir
Damghan University
University Blvd, Damghan, IR
Associate Professor of Physiology
Physiology
TarbiatModares University, Tehran, Iran
Physiology
TarbiatModares University, Tehran, Iran
DOI: 10.1016/j.nlm.2018.11.009
AUTHOR KEYWORDS: Anxiety; Hippocampus; Orexin receptors; Social novelty; Stress
DOI: 10.1007/s12640-018-9979-y
AUTHOR KEYWORDS: Folic acid; Homocysteine; Oxidative stress; Purkinje cell; Rat
DOI: 10.1097/WNR.0000000000001025
AUTHOR KEYWORDS: epigenetic; memory; opioid; rat; transgenerational
INDEX KEYWORDS: histone deacetylase 2; methyl CpG binding protein 2; morphine; tap water, animal experiment; Article; birth; conception; controlled study; drug use; female; hippocampus; male; maternal exposure; Morris water maze test; mother; nonhuman; prepregnancy care; priority journal; progeny; protein expression; rat; real time polymerase chain reaction; sex difference; spatial learning; spatial memory; Wistar rat
DOI: 10.1016/j.pbb.2017.05.004
AUTHOR KEYWORDS: Glutamate receptor; Histamine; Orexin 2 receptor; Posterior hypothalamus; PTZ; Seizure
INDEX KEYWORDS: 6 cyano 7 nitro 2,3 quinoxalinedione; glutamic acid; histamine; pentetrazole; glutamic acid; pentetrazole, adult; animal experiment; animal model; animal tissue; Article; controlled study; drug effect; latent period; male; nonhuman; pentylenetetrazole-induced seizure; posterior hypothalamus; priority journal; rat; rat model; tonic clonic seizure; animal; chemically induced; drug effects; histamine release; hypothalamus; metabolism; pathophysiology; seizure; Wistar rat, Animals; Glutamic Acid; Histamine Release; Hypothalamus; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures
DOI: 10.22038/ijbms.2017.9004
AUTHOR KEYWORDS: Epilepsy; Eugenol; Hippocampus; Mossy fiber sprouting; Oxidative stress
INDEX KEYWORDS: eugenol; glutathione peroxidase; lithium; malonaldehyde; pilocarpine; superoxide dismutase; thiobarbituric acid reactive substance, animal model; animal tissue; Article; behavior assessment; biochemical analysis; brain histology; cell count; cell survival; controlled study; convulsion; experimental epilepsy; hippocampus; male; nonhuman; oxidative stress; protein content; rat
DOI: 10.1016/j.ejphar.2017.01.005
AUTHOR KEYWORDS: Astrocyte; Epilepsy; GLT-1 transporter; Glutamine synthetase; β-estradiol
INDEX KEYWORDS: 4 aminobutyric acid; estradiol; glutamate ammonia ligase; glutamic acid; lithium; pilocarpine; sodium glucose cotransporter 1; estradiol; excitatory amino acid transporter 2; glutamate ammonia ligase; pilocarpine; Slc1a2 protein, rat, animal experiment; animal model; animal tissue; anticonvulsant activity; Article; astrocyte; cell density; chronic drug administration; clonic seizure; controlled study; drug megadose; drug screening; enzyme activity; female; hippocampus; latent period; nerve cell excitability; neuroprotection; nonhuman; protein expression; rat; animal; astrocyte; body weight; chemically induced; disease model; dose response; drug effects; metabolism; nerve cell; pathology; Seizures; Wistar rat, Animals; Astrocytes; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Excitatory Amino Acid Transporter 2; Female; Glutamate-Ammonia Ligase; Hippocampus; Neurons; Pilocarpine; Rats; Rats, Wistar; Seizures
AUTHOR KEYWORDS: Anxiety; Melatonin; Post-Traumatic Stress Disorder; Rats
INDEX KEYWORDS: melatonin, animal experiment; animal model; anxiety disorder; Article; controlled study; disease association; electric shock; elevated plus maze test; forced swim test; male; nonhuman; outcome assessment; posttraumatic stress disorder; rat
DOI: 10.1016/j.neuropharm.2016.07.005
AUTHOR KEYWORDS: CRH; HPA axis; Orexin; PTZ; Seizure; Stress
INDEX KEYWORDS: 4 aminobutyric acid; corticosterone; corticotropin releasing factor receptor 1; glutamic acid; messenger RNA; orexin; pentetrazole; 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine; aniline derivative; corticotropin releasing factor receptor; corticotropin releasing factor receptor 1; orexin; pentetrazole; pyrimidine derivative, adult; animal experiment; animal model; animal tissue; Article; blood level; brain function; brain region; controlled study; disease activity; disease association; disease duration; footshock; gene expression; lateral hypothalamus; male; molecular dynamics; molecular pathology; nonhuman; priority journal; protein determination; protein expression; protein function; rat; reverse transcription polymerase chain reaction; seizure; stress; animal; antagonists and inhibitors; biosynthesis; chemically induced; drug effects; lateral hypothalamus; mental stress; metabolism; prevention and control; psychology; seizure; Wistar rat, Aniline Compounds; Animals; Hypothalamic Area, Lateral; Male; Orexins; Pentylenetetrazole; Pyrimidines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Seizures; Stress, Psychological
DOI: 10.22038/ijbms.2016.7362
AUTHOR KEYWORDS: Acute stress; Chronic stress; Memory retrieval; Morris water maze; Rat
INDEX KEYWORDS: acute stress; adult; animal experiment; animal model; Article; chronic stress; controlled study; corticosterone blood level; enzyme linked immunosorbent assay; male; memory consolidation; memory disorder; Morris water maze test; nonhuman; rat
DOI: 10.1016/j.physbeh.2015.06.040
AUTHOR KEYWORDS: Lead acetate; Melatonin; Oxidative stress; Purkinje cell; Rat
INDEX KEYWORDS: glutathione peroxidase; lead; melatonin; scavenger; superoxide dismutase; thiobarbituric acid reactive substance; glutathione peroxidase; lead; melatonin; neuroprotective agent; superoxide dismutase; thiobarbituric acid reactive substance, animal experiment; animal model; animal tissue; Article; cerebellum; controlled study; enzyme activity; experimental locomotor activity test; female; histopathology; lipid peroxidation; male; neuroprotection; neurotoxicity; nonhuman; oxidative stress; pregnancy; priority journal; rat; rotarod test; adverse effects; animal; drug effects; maternal exposure; metabolism; Movement Disorders; oxidative stress; pathology; pathophysiology; prenatal exposure; randomization; Wistar rat, Animals; Cerebellum; Female; Glutathione Peroxidase; Lead; Lipid Peroxidation; Maternal Exposure; Melatonin; Movement Disorders; Neuroprotective Agents; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances
DOI: 10.1016/j.bbr.2015.03.022
AUTHOR KEYWORDS: Ethanol; Homocysteine; Melatonin; Oxidative stress; Purkinje cell; Rat
INDEX KEYWORDS: alcohol; catalase; glutathione peroxidase; homocysteine; melatonin; messenger RNA; protein Bax; protein bcl 2; sodium chloride; superoxide dismutase; thiobarbituric acid reactive substance; alcohol; Bax protein, rat; catalase; central depressant agent; glutathione peroxidase; homocysteine; melatonin; messenger RNA; neuroprotective agent; protein Bax; protein bcl 2; superoxide dismutase, adult; amino acid blood level; animal experiment; animal model; animal tissue; Article; cerebellum injury; cerebellum vermis; controlled study; drug effect; environmental exposure; enzyme activity; evening dosage; female; lipid peroxidation; locomotion; male; motor dysfunction; neuroprotection; neurotoxicity; nonhuman; oxidative stress; priority journal; protein expression; Purkinje cell; rat; rotarod test; animal; blood; cerebellum; drug effects; growth, development and aging; metabolism; oxidative stress; pathology; physiology; pregnancy; prenatal exposure; prevention and control; randomization; Wistar rat, Animals; bcl-2-Associated X Protein; Catalase; Central Nervous System Depressants; Cerebellum; Ethanol; Female; Glutathione Peroxidase; Homocysteine; Lipid Peroxidation; Locomotion; Melatonin; Neuroprotective Agents; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats, Wistar; RNA, Messenger; Superoxide Dismutase
DOI: 10.1016/j.pbb.2015.01.006
AUTHOR KEYWORDS: GABA; Glutamate; Orexin receptor antagonist; Pentylenetetrazol; Seizures
INDEX KEYWORDS: 1 (2 methyl 6 benzoxazolyl) 3 (1,5 naphthyridin 4 yl)urea; 4 aminobutyric acid; agents interacting with transmitter, hormone or drug receptors; glutamic acid; orexin 1 receptor; orexin 2 receptor; orexin 2 receptor antagonist; unclassified drug; 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea; 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-((4-pyridinylmethyl)amino)-1-butanone; 4 aminobutyric acid; benzoxazole derivative; convulsant agent; glutamic acid; isoquinoline derivative; orexin receptor; orexin receptor antagonist; pentetrazole; pyridine derivative; urea, animal experiment; animal model; Article; behavior assessment; clinical effectiveness; clinical evaluation; comparative study; controlled study; convulsion; disease duration; dose response; hippocampus; male; neuromodulation; neurotransmission; nonhuman; pentylenetetrazole-induced seizure; priority journal; protein determination; protein expression; rat; treatment duration; analogs and derivatives; animal; antagonists and inhibitors; chemically induced; drug effects; hippocampus; metabolism; microinjection; seizure, Rattus, Animals; Benzoxazoles; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Isoquinolines; Male; Microinjections; Orexin Receptor Antagonists; Orexin Receptors; Pentylenetetrazole; Pyridines; Rats; Seizures; Urea
DOI: 10.1159/000381358
AUTHOR KEYWORDS: Coronary artery disease; Lipid profile; PPAR-γ C1431T polymorphism
INDEX KEYWORDS: peroxisome proliferator activated receptor gamma; lipid; peroxisome proliferator activated receptor gamma, adult; angiography; anthropometric parameters; Article; controlled study; coronary artery disease; dyslipidemia; female; genotype; human; lipid blood level; major clinical study; male; measurement; priority journal; blood; coronary artery disease; cross-sectional study; diet restriction; genetic polymorphism; genetic predisposition; genetics; middle aged; odds ratio, Adult; Coronary Disease; Cross-Sectional Studies; Fasting; Female; Genetic Predisposition to Disease; Genotype; Humans; Lipids; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; PPAR gamma
DOI: 10.1016/j.bbr.2014.05.015
AUTHOR KEYWORDS: Chronic stress; Oxidative stress; Quercetin; Rat; Spatial memory
INDEX KEYWORDS: corticosterone; glutathione peroxidase; malonaldehyde; quercetin; superoxide dismutase; antioxidant; corticosterone; glutathione peroxidase; malonaldehyde; quercetin; superoxide dismutase, amnesia; analysis of variance; animal experiment; animal model; antioxidant activity; article; chronic stress; cognition; controlled study; corticosterone blood level; diet therapy; enzyme activity; hippocampus; immobilization stress; latent period; memory consolidation; Morris water maze test; neuroprotection; nonhuman; oxidative stress; priority journal; probe test; rat; spatial learning; training; animal; blood; complication; drug effects; exercise; male; maze test; Memory Disorders; mental stress; metabolism; neuropsychological test; procedures; psychology; spatial learning; spatial memory; time; treatment outcome; Wistar rat, Animals; Antioxidants; Corticosterone; Glutathione Peroxidase; Hippocampus; Male; Malondialdehyde; Maze Learning; Memory Disorders; Neuropsychological Tests; Quercetin; Rats; Rats, Wistar; Restraint, Physical; Spatial Learning; Spatial Memory; Stress, Psychological; Superoxide Dismutase; Time Factors; Treatment Outcome
DOI: 10.1016/j.ejphar.2014.02.041
AUTHOR KEYWORDS: 17β-estradiol; Brain derived neurotrophic factor; Ethanol; Neuroprotection; Purkinje cell
INDEX KEYWORDS: alcohol; brain derived neurotrophic factor; complementary DNA; estradiol; messenger RNA; alcohol; brain derived neurotrophic factor; central depressant agent; estradiol; neuroprotective agent, alcohol blood level; animal behavior; animal tissue; article; cell loss; cerebellum; controlled study; DNA synthesis; drug mechanism; enzyme linked immunosorbent assay; experimental locomotor activity test; female; histology; male; motor dysfunction; neuroprotection; newborn; nonhuman; open field test; perinatal period; priority journal; protein expression; Purkinje cell; rat; reverse transcription polymerase chain reaction; RNA extraction; rotarod test; animal; blood; cerebellum; drug effects; metabolism; motor activity; pathology; psychomotor performance; signal transduction, Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Central Nervous System Depressants; Cerebellum; Estradiol; Ethanol; Motor Activity; Neuroprotective Agents; Psychomotor Performance; Rats; Signal Transduction
DOI: 10.1016/j.physbeh.2014.02.040
AUTHOR KEYWORDS: Adult offspring; Corticosterone; Learning and memory; Morris water maze; Prenatal stress
INDEX KEYWORDS: corticosterone; corticosterone, adult; animal experiment; article; birth weight; controlled study; corticosterone blood level; female; first trimester pregnancy; food deprivation; heterogeneous sequential stress; immobilization stress; latent period; learning; male; memory; Morris water maze test; nonhuman; prenatal stress; priority journal; progeny; rat; second trimester pregnancy; spatial learning; swimming; third trimester pregnancy; water deprivation; animal; blood; complication; Learning Disorders; maze test; Memory Disorders; mental stress; neuropsychological test; pregnancy; prenatal exposure; task performance; time; Wistar rat, Animals; Birth Weight; Corticosterone; Female; Learning Disorders; Male; Maze Learning; Memory Disorders; Neuropsychological Tests; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Stress, Psychological; Swimming; Task Performance and Analysis; Time Factors
AUTHOR KEYWORDS: Harmaline; Rat; Riluzole; Tremor
INDEX KEYWORDS: harmaline; riluzole, animal experiment; animal model; article; controlled study; disease duration; disease severity; drug effect; drug efficacy; experimental study; latent period; male; nonhuman; rat; treatment response; tremor; Wistar rat
AUTHOR KEYWORDS: Kindling; Pentylenetetrazol; Pregnancy; Seizure; Stress
INDEX KEYWORDS: animal experiment; animal model; animal tissue; article; clonic seizure; controlled study; disease course; female; immobilization stress; kindling; male; nonhuman; pregnancy; rat; seizure threshold; stress; tonic clonic seizure
DOI: 10.1016/j.pbb.2014.05.020
INDEX KEYWORDS: Erratum; retracted article
AUTHOR KEYWORDS: Convulsion; Epileptogenesis; Kindling development; Orexinergic system; Pentylenetetrazol
INDEX KEYWORDS: 1 (2 methyl 6 benzoxazolyl) 3 (1,5 naphthyridin 4 yl)urea; glutamic acid; lidocaine; orexin 1 receptor; orexin A; pentetrazole, amino acid brain level; animal experiment; animal model; animal tissue; article; controlled study; convulsion; drug mechanism; drug receptor binding; hippocampus; hypothalamus; kindling; lateral hypothalamus; male; nerve excitability; neuromodulation; nonhuman; rat; receptor blocking; seizure
Methods: SPS&S model was used to induce PTSD in 56 male Wistar rats. Rats were restrained for 2 h, immediately followed by forced swimming for 20 min. After 15 min of recuperation, animals were exposed to diethyl ether until they lost consciousness. Thirty min later, rats received an electric foot shock in a shock chamber. Rats which were in the shock group, without experiencing SPS, only received an electrical foot shock. Animals received IP injections of WIN (two doses) or vehicle, before tests, in 3 continuous days. For PTSD induction, conditioned fear response was measured. Anxiety-like behavior was examined twice with elevated plus-maze.
Results: PTSD induction with SPS&S significantly decreased open arm time (OAT) and open arm entry (OAE) parameter, as compared to the control. WIN (0.25 mg/kg) significantly increased OAT as compared with the control.
Conclusion: WIN (0.25 mg/kg) decreased the anxiety like behavior induced by PTSD, so it seems to have antianxiety effect. © 2014, National Research Council of Canada. All rights reserved.
AUTHOR KEYWORDS: Anxiety; Cannabinoid receptors; Post-traumatic stress disorder; WIN55-212-2
INDEX KEYWORDS: cannabinoid receptor agonist; unclassified drug; win55-212-2, animal experiment; animal model; anxiety; Article; controlled study; electric shock; elevated plus maze test; fear; forced swim test; male; nonhuman; posttraumatic stress disorder; rat
AUTHOR KEYWORDS: Conditioning; Ethanol; Hippocampus; Reconsolidation
INDEX KEYWORDS: alcohol; paraformaldehyde; pentobarbital; phosphate buffered saline, analysis of variance; animal cell; animal experiment; animal model; animal tissue; article; behavior; clinical examination; conditioning; controlled study; dentate gyrus; experimental study; fear; granule cell; hippocampal CA1 region; hippocampal CA3 region; histology; male; medical research; memory; nonhuman; perfusion; rat
DOI: 10.1016/j.ejphar.2012.08.014
AUTHOR KEYWORDS: (Rat); Cerebellum; Harmaline; Riluzole; Tremor
INDEX KEYWORDS: riluzole, animal behavior; animal experiment; animal model; animal tissue; article; ataxia; cerebellum; controlled study; dose response; drug dose comparison; drug effect; histopathology; motor performance; neuromodulation; neuroprotection; neurotransmission; nonhuman; open field test; priority journal; Purkinje cell; rat; rotarod test; tremor, Animals; Ataxia; Behavior, Animal; Cerebellum; Glutamates; Harmaline; Ion Channels; Male; Neuroprotective Agents; Rats; Rats, Wistar; Riluzole; Rotarod Performance Test; Time Factors; Tremor
DOI: 10.1016/j.pbb.2012.04.008
AUTHOR KEYWORDS: Contextual fear conditioning; Ethanol; Hippocampus; Reconsolidation
INDEX KEYWORDS: alcohol; paraformaldehyde; phosphate buffered saline, acute drug administration; animal cell; animal experiment; animal tissue; apoptosis; article; cell density; controlled study; dentate gyrus; drug effect; freezing; hippocampal CA1 region; hippocampal CA3 region; hippocampus; male; memory; nerve cell; nick end labeling; nonhuman; priority journal; rat; tissue fixation; tissue section, Animals; Apoptosis; Behavior, Animal; Ethanol; Hippocampus; Male; Memory; Neurons; Rats; Rats, Wistar, Animalia; Rattus; Rattus norvegicus
AUTHOR KEYWORDS: Cerebellum; Ethanol; Oxidative stress; Purkinje cell; Rat
INDEX KEYWORDS: alcohol; catalase; glutathione peroxidase; superoxide dismutase; thiobarbituric acid reactive substance, animal experiment; animal model; animal tissue; antioxidant activity; article; brain development; cerebellum vermis; controlled study; enzyme activity; histopathology; lipid peroxidation; male; microcephaly; neurotoxicity; newborn; nonhuman; oxidative stress; Purkinje cell; rat, Rattus
AUTHOR KEYWORDS: Chronic heterogeneous stress; Formalin test; Hot-plate; Pain; Rat
INDEX KEYWORDS: formaldehyde, animal experiment; article; chronic heterogeneous stress; controlled study; food deprivation; forced swim test; hot plate test; immobilization stress; male; nociception; nociceptive pain; nonhuman; rat; social isolation; stress; water deprivation
DOI: 10.1016/j.pbb.2011.07.010
AUTHOR KEYWORDS: 17β-estradiol; Ethanol; Lipid peroxidation; Oxidative stress; Purkinje cell; Rat pups
INDEX KEYWORDS: alcohol; catalase; estradiol; glutathione peroxidase; superoxide dismutase; thiobarbituric acid reactive substance, animal experiment; antioxidant activity; article; behavior change; biochemistry; brain development; cerebellum; cerebellum vermis; controlled study; female; histology; locomotion; male; neuroprotection; neurotoxicity; nonhuman; oxidative stress; perinatal period; priority journal; Purkinje cell; rat; rotarod test; task performance, Animals; Animals, Newborn; Cerebellum; Estradiol; Ethanol; Male; Motor Activity; Motor Skills Disorders; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar, Rattus
DOI: 10.1002/syn.20834
AUTHOR KEYWORDS: CA1 neural network; Epileptogenic insult; Primed burst stimulation; Synaptic plasticity; Theta pulse stimulation
INDEX KEYWORDS: adenosine; adenosine A1 receptor; pentetrazole, animal experiment; animal model; article; controlled study; epilepsy; epileptic focus; excitatory postsynaptic potential; hippocampal CA1 region; hippocampus theta rhythm; in vitro study; male; nonhuman; pattern stimulation; priority journal; pulse rate; rat; stimulation; stratum pyramidale; stratum radiatum
DOI: 10.1002/bem.20567
AUTHOR KEYWORDS: Diabetes; Pulsed electromagnetic field; Rat; Streptozocin; Wound healing
INDEX KEYWORDS: Animalia; Rattus; Rattus norvegicus, streptozocin, animal; article; electromagnetic field; experimental diabetes mellitus; injury; male; pathophysiology; radiation exposure; rat; skin; tensile strength; Wistar rat; wound healing, Animals; Diabetes Mellitus, Experimental; Electromagnetic Fields; Male; Rats; Rats, Wistar; Skin; Streptozocin; Tensile Strength; Wound Healing
DOI: 10.1111/j.1528-1167.2008.01802.x
AUTHOR KEYWORDS: Addiction; CA1 neural network; Long-term depression; Long-term potentiation; Seizure; Synaptic plasticity
INDEX KEYWORDS: morphine; naloxone; pentetrazole, animal experiment; animal model; animal tissue; article; brain electrophysiology; controlled study; epilepsy; epileptic discharge; hippocampus; in vitro selection; male; morphine addiction; nerve cell plasticity; nonhuman; priority journal; rat; spike wave, Animals; Convulsants; Disease Models, Animal; Drug Interactions; Electric Stimulation; Evoked Potentials; Hippocampus; Long-Term Potentiation; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Neural Pathways; Pentylenetetrazole; Rats; Rats, Inbred Strains; Statistics, Nonparametric; Substance Withdrawal Syndrome